Endochondral bone tissue engineering using embryonic stem cells
نویسندگان
چکیده
منابع مشابه
Endochondral bone tissue engineering using embryonic stem cells.
Embryonic stem cells can provide an unlimited supply of pluripotent cells for tissue engineering applications. Bone tissue engineering by directly differentiating ES cells (ESCs) into osteoblasts has been unsuccessful so far. Therefore, we investigated an alternative approach, based on the process of endochondral ossification. A cartilage matrix was formed in vitro by mouse ESCs seeded on a sca...
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In extensive bone defects, tissue damage and hypoxia lead to cell death, resulting in slow and incomplete healing. Human embryonic stem cells (hESC) can give rise to all specialized lineages found in healthy bone and are therefore uniquely suited to aid regeneration of damaged bone. We show that the cultivation of hESC-derived mesenchymal progenitors on 3D osteoconductive scaffolds in bioreacto...
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Tissue engineering is an interdisciplinary science that involves the use of biological sciences and engineering to develop tissues that restore, maintain, or enhance tissue function. However, to realize the dream of creating off-the-shelf organs for transplantation, a renewable source of cells is required. Embryonic stem (ES) cells have the potential to provide such a source of cells for tissue...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0711662105